AMYLOID PRECURSOR PROTEIN Meaning and
Definition
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Amyloid precursor protein (APP) is a transmembrane protein that is primarily found in the brain and central nervous system. It is involved in the formation and regulation of beta-amyloid plaques, which are characteristic of several neurodegenerative diseases, including Alzheimer's disease.
The APP gene encodes the amyloid precursor protein, which is initially produced as a larger protein molecule. Through a series of enzymatic cleavages, APP is processed into various fragments, including beta-amyloid peptides. These fragments can aggregate and form insoluble plaques in the brain, which can disrupt normal neuronal communication and contribute to the development of neurodegenerative diseases.
In addition to its involvement in plaque formation, amyloid precursor protein is also thought to have important roles in neuronal development and survival, synaptic plasticity, and cell signaling. It may play a role in promoting cell adhesion and neuronal migration during development, and it has been implicated in the regulation of synaptic transmission and plasticity, which are crucial for learning and memory processes.
Dysfunction or abnormal processing of amyloid precursor protein can lead to the accumulation of beta-amyloid peptides and the subsequent development of amyloid plaques, which are pathological hallmarks of Alzheimer's disease. Research into the mechanisms and functions of APP is ongoing, with the aim of developing therapeutic strategies to target this protein and potentially halt or slow down the progression of neurodegenerative diseases.
Common Misspellings for AMYLOID PRECURSOR PROTEIN
- zmyloid precursor protein
- smyloid precursor protein
- wmyloid precursor protein
- qmyloid precursor protein
- anyloid precursor protein
- akyloid precursor protein
- ajyloid precursor protein
- amtloid precursor protein
- amgloid precursor protein
- amhloid precursor protein
- amuloid precursor protein
- am7loid precursor protein
- am6loid precursor protein
- amykoid precursor protein
- amypoid precursor protein
- amyooid precursor protein
- amyliid precursor protein
- amylkid precursor protein
- amyllid precursor protein
- amylpid precursor protein
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