ANGIOGENIC FACTOR Meaning and
Definition
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Angiogenic factor refers to a substance or molecule that stimulates the growth of new blood vessels from pre-existing ones, a process known as angiogenesis. It plays a crucial role in various physiological and pathological processes, including wound healing, tissue development, and tumor progression.
When angiogenesis is necessary, such as during tissue repair, an angiogenic factor is released either from cells in the surrounding tissues or through the activation of certain signaling pathways. These factors can include vascular endothelial growth factors (VEGFs), fibroblast growth factors (FGFs), platelet-derived growth factors (PDGFs), and many others. Angiogenic factors bind to specific receptors on endothelial cells, the primary cells lining blood vessels, initiating a cascade of events that leads to the formation of new blood vessels. This process involves endothelial cell proliferation, migration, and the degradation of the existing extracellular matrix. As a result, new capillary sprouts emerge, which eventually mature into fully functional blood vessels.
Angiogenic factors are essential during embryonic development, where they contribute to the formation of vascular networks. In adults, they play a role in healing, where they help supply oxygen and nutrients to injured tissues. Angiogenesis is also critical in cancer development, as tumors require a sufficient blood supply to grow and metastasize. Therefore, angiogenic factors have become sought-after targets for therapeutic interventions aimed at inhibiting tumor growth and controlling pathological angiogenesis.
Common Misspellings for ANGIOGENIC FACTOR
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Etymology of ANGIOGENIC FACTOR
The word "angiogenic" is derived from the Ancient Greek words "angeion" meaning "vessel" and "genesis" meaning "beginning" or "creation". When combined, "angiogenic" refers to "vessel formation" or the process of creating new blood vessels.
The word "factor" comes from Latin "factor" meaning "maker" or "doer". In this context, "factor" refers to a substance or entity that plays a role or has an effect on a specific process or function. In the case of "angiogenic factor", it refers to a molecule or protein that promotes the formation of new blood vessels (angiogenesis).
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