CALLICREIN Meaning and
Definition
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Callicrein, also known as Kallikrein, is a family of serine proteases that play crucial roles in various physiological and pathological processes. These enzyme molecules are primarily found in tissues such as the pancreas, salivary glands, and kidneys. One of the most well-known examples of callicrein is tissue kallikrein.
Callicrein enzymes are responsible for the cleavage of specific peptide bonds within proteins. They have a diverse range of substrates and are involved in various biological processes, including blood pressure regulation, inflammation, tissue remodeling, and ion transport. The name "callicrein" is derived from its ability to activate kinins, which are potent vasodilators involved in blood pressure regulation.
In addition to their physiological functions, callicrein enzymes have been associated with several diseases. For example, an abnormal increase in tissue kallikrein activity is observed in conditions like asthma, cancer, and cardiovascular diseases. Callicrein inhibitors have emerged as potential therapeutic targets for these diseases due to their impact on crucial molecular pathways.
The discovery and understanding of callicrein enzymes have significantly contributed to the fields of biochemistry, physiology, and medicine. Ongoing research is focused on elucidating the precise mechanisms of action, identifying novel substrates, and developing therapeutic interventions targeting callicrein enzymes. Overall, the study of callicrein plays a vital role in advancing our knowledge of human physiology and holds promise for the development of new treatments for various diseases.
Common Misspellings for CALLICREIN
- xallicrein
- vallicrein
- fallicrein
- dallicrein
- czllicrein
- csllicrein
- cwllicrein
- cqllicrein
- caklicrein
- caplicrein
- caolicrein
- calkicrein
- calpicrein
- caloicrein
- callucrein
- calljcrein
- callkcrein
- callocrein
- call9crein
- call8crein
Etymology of CALLICREIN
The word "callicrein" derives from the Ancient Greek term "kalos", meaning "beautiful", and "kreas", meaning "flesh". The combination of these two elements forms "kalokreas", which can be translated to "beautiful flesh". The term "callicrein" originated from this Greek term and is used to refer to a group of proteolytic enzymes involved in various physiological processes.
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