CHLORIDE BICARBONATE ANTIPORTERS Meaning and
Definition
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Chloride bicarbonate antiporters are transmembrane proteins that play a crucial role in maintaining the balance of chloride (Cl-) and bicarbonate (HCO3-) ions across cellular membranes. They facilitate the exchange of these ions in opposite directions, actively transporting one ion into the cell while simultaneously removing the other ion from it. This process of antiportation is essential for various physiological functions, especially in maintaining proper pH levels and regulating cellular osmotic balance.
Chloride bicarbonate antiporters are commonly found in cell membranes, including those of the kidneys, intestines, and lungs, where they contribute to the reabsorption of bicarbonate and the secretion of chloride ions. By removing excess chloride ions and allowing the influx of bicarbonate, these antiporters help in regulating acid-base balance and maintaining systemic pH within a narrow range.
The activity of chloride bicarbonate antiporters is controlled by various factors, including changes in intracellular pH and intracellular chloride concentrations. Dysregulation or dysfunction of these antiporters can disrupt the delicate balance of bicarbonate and chloride ions, leading to conditions such as metabolic acidosis or alkalosis. Moreover, mutations in the genes encoding these antiporters can result in genetic disorders like congenital chloride-losing diarrhea.
Understanding the function and regulation of chloride bicarbonate antiporters is crucial in elucidating the underlying mechanisms of acid-base balance and ion transport. Their therapeutic potential has also been recognized, as modulating their activity may provide opportunities for developing drugs to target conditions associated with aberrant chloride and bicarbonate ion transport.
Common Misspellings for CHLORIDE BICARBONATE ANTIPORTERS
- xhloride bicarbonate antiporters
- vhloride bicarbonate antiporters
- fhloride bicarbonate antiporters
- dhloride bicarbonate antiporters
- cgloride bicarbonate antiporters
- cbloride bicarbonate antiporters
- cnloride bicarbonate antiporters
- cjloride bicarbonate antiporters
- culoride bicarbonate antiporters
- cyloride bicarbonate antiporters
- chkoride bicarbonate antiporters
- chporide bicarbonate antiporters
- chooride bicarbonate antiporters
- chliride bicarbonate antiporters
- chlkride bicarbonate antiporters
- chllride bicarbonate antiporters
- chlpride bicarbonate antiporters
- chl0ride bicarbonate antiporters
- chl9ride bicarbonate antiporters
- chloeide bicarbonate antiporters
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