CILIARY NEUROTROPHIC FACTOR RECEPTOR Meaning and
Definition
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Ciliary neurotrophic factor receptor (CNTFR) is a transmembrane protein that plays a key role in the signaling pathway of ciliary neurotrophic factor (CNTF), a cytokine involved in neural cell development and survival. The CNTFR protein is primarily found in the nervous system and is abundantly expressed in neurons.
The CNTFR protein is composed of multiple subunits, including the CNTFRα subunit and two additional subunits, gp130 and LIFRβ. These subunits form a receptor complex necessary for CNTF binding and subsequent activation of downstream signaling cascades. The binding of CNTF to the CNTFRα subunit triggers the recruitment of gp130 and LIFRβ, resulting in the assembly of a functional receptor complex that initiates intracellular signaling.
Upon activation, the CNTFR complex activates various downstream signaling pathways, such as the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. This signaling cascade regulates gene expression, cellular differentiation, and survival in neurons. The activation of CNTFR also promotes the production of neurotrophic factors, which enhance the survival and functionality of nerve cells.
Mutations or dysregulation of CNTFR can lead to abnormal neural development and function, potentially resulting in neurodevelopmental disorders or neurodegenerative diseases. Researchers are actively studying the role of CNTFR and its signaling pathways in various neurological disorders, with the aim of developing therapeutic strategies targeting this receptor complex for the treatment of neurodegenerative diseases and nerve injury.
Common Misspellings for CILIARY NEUROTROPHIC FACTOR RECEPTOR
- xiliary neurotrophic factor receptor
- viliary neurotrophic factor receptor
- filiary neurotrophic factor receptor
- diliary neurotrophic factor receptor
- culiary neurotrophic factor receptor
- cjliary neurotrophic factor receptor
- ckliary neurotrophic factor receptor
- coliary neurotrophic factor receptor
- c9liary neurotrophic factor receptor
- c8liary neurotrophic factor receptor
- cikiary neurotrophic factor receptor
- cipiary neurotrophic factor receptor
- cioiary neurotrophic factor receptor
- ciluary neurotrophic factor receptor
- ciljary neurotrophic factor receptor
- cilkary neurotrophic factor receptor
- ciloary neurotrophic factor receptor
- cil9ary neurotrophic factor receptor
- cil8ary neurotrophic factor receptor
- cilizry neurotrophic factor receptor
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