How Do You Spell INSULIN LIKE GROWTH FACTOR II RECEPTOR?

1. Insulin Like Growth Factor II Receptor (IGF2R) is a type of transmembrane protein receptor that plays an essential role in regulating cellular growth and development. It is also known as the IGF2 binding protein 2 receptor (IGFBP2R) or cation-independent mannose-6-phosphate receptor (CI-MPR).

   The IGF2R is primarily found on the cell surface and is involved in binding and regulating the actions of insulin-like growth factors, specifically insulin-like growth factor II (IGF-II). It functions as a high-affinity binding receptor, allowing the specific uptake of IGF-II from the extracellular space into the cells. This receptor-ligand interaction effectively removes IGF-II from the circulation, preventing its uncontrolled activity and maintaining cellular homeostasis.

   Furthermore, the IGF2R is responsible for facilitating the transport of newly synthesized lysosomal enzymes from the Golgi apparatus to the lysosomes. This process is achieved through the recognition and binding of mannose-6-phosphate residues on these enzymes to the receptor, leading to their internalization and delivery to the lysosomes. Thus, IGF2R not only regulates growth factors but also plays a crucial role in lysosomal enzyme trafficking, promoting efficient protein degradation in the cells.

   Abnormalities or deficiencies in the IGF2R expression or function have been linked to various pathological conditions, including cancer, insulin resistance, and developmental disorders. Consequently, the study of the IGF2R and its mechanisms has significant implications in understanding disease pathogenesis and developing potential therapeutic interventions.

Common Misspellings for INSULIN LIKE GROWTH FACTOR II RECEPTOR

Similar spelling words for INSULIN LIKE GROWTH FACTOR II RECEPTOR