PROLINE ROTAMASE Meaning and
Definition
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Proline rotamase, commonly referred to as prolyl isomerase or peptidyl-prolyl cis-trans isomerase (PPIase), is an enzyme that catalyzes the rotation (isomerization) of the peptide bond preceding a proline residue. This enzyme plays a fundamental role in protein folding and function.
Proline, a unique amino acid, is commonly found in proteins and is known for its rigid and cyclic structure. Due to this characteristic, the rotation of the peptide bonds on both sides of proline is typically restricted, making proline-rich regions less flexible compared to other amino acids. This restricted rotation can affect protein folding, conformation, and stability.
Proline rotamase provides a catalytic function in facilitating the interconversion between two stable conformations of the peptide bond, namely cis and trans, adjacent to proline residues. By catalyzing this conversion, proline rotamase enhances the flexibility of proline-rich regions, allowing for proper protein folding and facilitating protein-protein interactions.
The enzymatic activity of proline rotamase is crucial in various biological processes, including protein folding, molecular chaperone activity, signal transduction, and cell membrane receptor assembly. Dysregulation of proline rotamase activity has been associated with numerous diseases, such as cancer, neurodegenerative disorders, and autoimmune diseases.
In summary, proline rotamase is an enzyme that catalyzes the rotation (isomerization) of the peptide bond adjacent to proline residues. This isomerization process enables the flexibility and conformational changes necessary for proper protein folding and functionality in various biological processes.
Common Misspellings for PROLINE ROTAMASE
- oroline rotamase
- lroline rotamase
- -roline rotamase
- 0roline rotamase
- peoline rotamase
- pdoline rotamase
- pfoline rotamase
- ptoline rotamase
- p5oline rotamase
- p4oline rotamase
- priline rotamase
- prkline rotamase
- prlline rotamase
- prpline rotamase
- pr0line rotamase
- pr9line rotamase
- prokine rotamase
- propine rotamase
- prooine rotamase
- prolune rotamase
Etymology of PROLINE ROTAMASE
The word "proline" derives from the Greek word "pro" (meaning "before" or "first") and the Latin word "linum" (meaning "thread"). It was named so because proline is the only proteinogenic amino acid that forms a cyclic structure, leading to a distinctive "kink" in the protein chain.
The term "rotamase" is a combination of "rotation" and "isomerase". "Rotation" refers to the ability of a molecule to rotate around a specific bond, while "isomerase" refers to an enzyme that catalyzes the conversion of one isomer to another. Rotamases are enzymes involved in the isomerization or interconversion of different conformations (rotamers) of amino acids in proteins.
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