PROPERDIN FACTOR B Meaning and
Definition
-
Properdin Factor B, also known as complement factor properdin or simply properdin, is a protein that forms part of the complement system, an important component of the immune system. It is encoded by the CFAB gene.
Properdin Factor B primarily functions as a positive regulator of the alternative pathway of the complement system. Complement, in general, is a group of proteins that participate in the immune response by aiding in the destruction of pathogens such as bacteria or viruses. The alternative pathway is one of the three pathways (alongside the classical and lectin pathways) through which the complement system can be activated.
Properdin Factor B is responsible for stabilizing the C3 convertase enzyme complex, which is crucial for the activation and amplification of the alternative pathway. It binds to the C3bBb complex and prevents its degradation, allowing for the continual generation of C3b, a key component of the complement cascade.
A deficiency or dysfunction of Properdin Factor B can lead to an increased susceptibility to infections caused by certain bacteria, particularly those that have evolved strategies to evade complement-mediated immunity. It has also been associated with autoimmune diseases and inflammatory disorders.
In summary, Properdin Factor B is a protein involved in the positive regulation of the alternative pathway of the complement system, contributing to the immune response against pathogens and maintaining overall immune homeostasis.
Common Misspellings for PROPERDIN FACTOR B
- oroperdin factor b
- lroperdin factor b
- -roperdin factor b
- 0roperdin factor b
- peoperdin factor b
- pdoperdin factor b
- pfoperdin factor b
- ptoperdin factor b
- p5operdin factor b
- p4operdin factor b
- priperdin factor b
- prkperdin factor b
- prlperdin factor b
- prpperdin factor b
- pr0perdin factor b
- pr9perdin factor b
- prooerdin factor b
- prolerdin factor b
- pro-erdin factor b
- pro0erdin factor b
Infographic
Add the infographic to your website:
