TIGHT JUNCTIONS Meaning and
Definition
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Tight junctions, also known as occluding junctions or zonula occludens, are specialized cell junctions found in epithelial and endothelial tissues. They are intercellular connections that play a crucial role in establishing a barrier between adjacent cells, preventing the passage of substances through the intercellular space.
These junctions are formed by a complex network of proteins that physically link the plasma membranes of neighboring cells together, creating a seal-like structure. The proteins involved in the formation of tight junctions include claudins, occludins, and junctional adhesion molecules (JAMs).
Tight junctions primarily function to regulate the permeability of epithelial and endothelial tissues. By forming a continuous belt-like structure around the cells, they prevent the leakage of molecules, ions, and fluids between the cells, thereby maintaining the integrity of the tissue barrier. This selective permeability restricts the passage of harmful substances, toxins, and pathogens, while allowing the controlled transport of essential molecules and ions.
In addition to their barrier function, tight junctions also have a role in cell signaling and communication. They help in maintaining tissue polarity and organization, regulating cell proliferation, differentiation, and movement. Furthermore, tight junctions contribute to the establishment and maintenance of cell polarity in epithelial cells, which is vital for the proper functioning of organs and tissues.
Overall, tight junctions are essential structural components that regulate the permeability of epithelial and endothelial barriers and play a critical role in maintaining tissue homeostasis and function.
Common Misspellings for TIGHT JUNCTIONS
- right junctions
- fight junctions
- gight junctions
- yight junctions
- 6ight junctions
- 5ight junctions
- tught junctions
- tjght junctions
- tkght junctions
- toght junctions
- t9ght junctions
- t8ght junctions
- tifht junctions
- tivht junctions
- tibht junctions
- tihht junctions
- tiyht junctions
- titht junctions
- tiggt junctions
- tigbt junctions
Etymology of TIGHT JUNCTIONS
The word "tight junctions" derives from the Latin word "iacere" meaning "to join" or "to fasten together". The Latin word "iacere" then evolved into the Old French word "joindre", which means "to join" or "to connect". In the late 16th century, the Old French word was borrowed into English as "join". The adjective "tight" was added to describe the closely connected or close-knit nature of these junctions. Eventually, the term "tight junctions" came to refer to the specialized connections between cells that form a barrier to control the passage of substances between tissues or organs.
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