TOPBP Meaning and
Definition
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TOPBP is an acronym that stands for "Topoisomerase II Binding Protein 1". It refers to a protein that plays a crucial role in regulating DNA repair and replication processes within a cell. The TOPBP protein is primarily involved in the activation of the DNA damage checkpoint response, which ensures the maintenance of genomic stability by halting cell cycle progression upon DNA damage or replication stress.
TOPBP interacts with various proteins involved in the response to DNA damage, including the ATR kinase, which is a key regulator of DNA damage checkpoint signaling. Through its interactions, TOPBP facilitates the recruitment and activation of ATR at sites of DNA damage, consequently triggering a signaling cascade that leads to cell cycle arrest and initiation of DNA repair.
This protein has been shown to have multiple functional domains that contribute to its diverse roles in cellular processes. For instance, it contains a conserved BRCT (BRCA1 C Terminus) domain that recognizes phosphorylated proteins, enabling TOPBP to bind to specific DNA damage response proteins. Additionally, TOPBP possesses an ATR-activating domain, which facilitates the activation of the ATR kinase to initiate checkpoint signaling.
Overall, TOPBP is an essential protein involved in the maintenance of genomic stability and coordination of DNA repair and replication processes in cells. Its multifaceted interactions and functional domains make it a key player in the DNA damage response pathway.
Common Misspellings for TOPBP
- yopbp
- 6opbp
- 5opbp
- tipbp
- tkpbp
- tlpbp
- tppbp
- t0pbp
- t9pbp
- toobp
- to0bp
- topvp
- tophp
- topbo
- topb0
- rtopbp
- gtopbp
- tgopbp
- ytopbp
- tyopbp
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