Transformed cell lines refer to cells that have undergone a process called transformation, resulting in genetic changes that allow them to proliferate indefinitely. These cell lines are derived from normal cells that have been altered by various methods, such as exposure to certain chemicals or viruses, or through genetic manipulation.
In biology, cells have a limited capacity to divide and multiply before reaching a state known as replicative senescence. However, transformed cell lines have acquired the ability to bypass this limitation and continuously divide, making them valuable tools in scientific research and biotechnology.
Transformed cell lines often exhibit characteristics such as abnormal growth patterns, altered morphology, and changes in gene expression compared to their normal counterparts. These alterations are a consequence of genetic mutations that affect crucial regulatory pathways controlling cell division, DNA repair, and apoptosis.
Scientists extensively utilize transformed cell lines to study fundamental biological processes, investigate disease mechanisms, develop new drugs, and produce various important substances. Furthermore, these cell lines can serve as models for human diseases, providing platforms for research and testing interventions.
It is worth noting that transformed cell lines are distinct from normal cell lines in terms of their behavior and genetic makeup. Their ability to propagate indefinitely and exhibit unique characteristics make them an invaluable resource in various scientific and medical applications.
