Substance K receptors, also known as neurokinin-1 (NK1) receptors, are a type of cell membrane receptor that plays a crucial role in the transmission of signals within the nervous system. These receptors are specifically activated by a neuropeptide known as substance K, which is a member of the tachykinin family of neurotransmitters.
Substance K receptors are primarily found in the central and peripheral nervous systems, as well as in various other tissues such as the gastrointestinal tract and the immune system. They are predominantly involved in mediating pain and inflammation responses, as well as regulating neurogenic inflammation, mood, and stress.
When substance K binds to the NK1 receptors, a cascade of intracellular events is triggered, leading to the activation of various signaling pathways. This activation ultimately results in the transmission of pain signals to the brain and the subsequent sensation of pain.
Furthermore, substance K receptors have been implicated in various pathological conditions, such as chronic pain, psychiatric disorders (including anxiety and depression), and neurodegenerative diseases. Due to their involvement in these conditions, substance K receptors have become an important target for the development of therapeutic drugs.
In summary, substance K receptors are cell membrane receptors that are specifically activated by substance K. They play a critical role in pain perception, inflammation, and various other physiological and pathological processes within the nervous system and other tissues.
