TETRAHYDROFOLATE DEHYDROGENASE Meaning and
Definition
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Tetrahydrofolate dehydrogenase is an enzyme involved in the metabolic pathway of folate. It plays a crucial role in converting tetrahydrofolate (THF) to dihydrofolate (DHF) by removing hydrogen from THF. THF is an essential cofactor in many biological reactions, including the synthesis of nucleotides, amino acids, and other important cellular components.
The enzyme tetrahydrofolate dehydrogenase is responsible for the specific chemical reaction that involves the transfer of hydrogen atoms from THF to an electron carrier, ultimately leading to the oxidation of THF and the formation of DHF. This reaction is a key step in folate metabolism, as it allows the recycling of THF for further use in cellular processes.
Tetrahydrofolate dehydrogenase is found in various tissues and organs, with particularly high levels observed in the liver, kidney, and gastrointestinal tract. Mutations in the gene encoding this enzyme have been associated with certain disorders, such as megaloblastic anemia, which is characterized by impaired DNA synthesis and abnormal red blood cell development.
Overall, tetrahydrofolate dehydrogenase is an essential enzyme that plays a fundamental role in folate metabolism, contributing to various cellular processes vital for normal growth, development, and overall health.
Common Misspellings for TETRAHYDROFOLATE DEHYDROGENASE
- retrahydrofolate dehydrogenase
- fetrahydrofolate dehydrogenase
- getrahydrofolate dehydrogenase
- yetrahydrofolate dehydrogenase
- 6etrahydrofolate dehydrogenase
- 5etrahydrofolate dehydrogenase
- twtrahydrofolate dehydrogenase
- tstrahydrofolate dehydrogenase
- tdtrahydrofolate dehydrogenase
- trtrahydrofolate dehydrogenase
- t4trahydrofolate dehydrogenase
- t3trahydrofolate dehydrogenase
- terrahydrofolate dehydrogenase
- tefrahydrofolate dehydrogenase
- tegrahydrofolate dehydrogenase
- teyrahydrofolate dehydrogenase
- te6rahydrofolate dehydrogenase
- te5rahydrofolate dehydrogenase
- teteahydrofolate dehydrogenase
- tetdahydrofolate dehydrogenase
Etymology of TETRAHYDROFOLATE DEHYDROGENASE
The word "Tetrahydrofolate" comes from the combination of "tetra-", which means four, "hydro", which refers to hydrogen, and "folate", a salt or ester of folic acid. Folic acid is a vitamin involved in various biological processes, including DNA synthesis and repair. "Dehydrogenase" is a combining form derived from "de-", meaning removal or reversal, and "hydrogenase", an enzyme that catalyzes the transfer of hydrogen from a substrate to an acceptor molecule. Thus, "Tetrahydrofolate Dehydrogenase" refers to an enzyme that catalyzes the removal of hydrogen from tetrahydrofolate.
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